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Increase signal-to-noise ratio for non-invasive and quantitative chemical microscopy
This microscope imaging technique dramatically enhances the chemical contrast of broadband non-linear Raman images by removing unwanted background signals and retaining resonant signals of interest. The approach uses pulse shaping and closed-form signal analysis to enhance image contrast of broadband non-linear Raman spectroscopy, such as coherent anti-Stokes Raman scattering (CARS) microscopy. Non-resonant background signals are suppressed by a compact pulse shaper to improve sensitivity and signal-to-noise ratio, thus providing high-contrast and high-sensitivity broadband non-linear Raman microscopy.
The invention disclosed herein is a novel and simple method of suppressing non-resonant background (NRB) in broadband coherent anti-Stokes Raman scattering (CARS) microscopy to improve sensitivity and signal-to-noise ratio.
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